Defining Prurigo Nodularis
Prurigo Nodularis (PN) is a skin condition where hard, itchy lumps form on the skin. Prurigo means itch, and nodularis means nodules. The itching caused by PN can be so intense that people often scratch themselves to the point of bleeding. The itching is made worse by sweating, heat, or irritation from clothes. If you have symptoms of PN, or have been diagnosed, read on for more info!
The Cause
The itching itself is what causes the nodules to form. When the skin is scratched repeatedly, it causes injury and the skin then protects itself by creating a thicker layer, which is where the nodules come from. This is called the itch-scratch cycle. Although the cause of PN is not always clear, certain conditions will increase the chances of someone developing PN. Some of those include:
- Psychological conditions
- Reduced liver or kidney function
- Allergies
- Skin diseases such as:
- Eczema
- Bullous Pemphigoid
- Dermatitis Herpetiformis
Diagnosis and Treatment
Excessive scratching also causes nerves to thicken in affected areas and these thicker nerves will then send stronger than normal itching sensations. A skin biopsy is usually performed to determine if PN is the cause of the itching, as a biopsy will show the thickened nerves. Other tests, such as blood, liver, and kidney tests, will also help to identify any underlying cause of the itch.
Treatment of PN is different for every patient and it may take several attempts to find a treatment plan that works for you. Common PN treatments are:
- Corticosteroid Creams are applied to nodules and covered with airtight and waterproof bandages to reduce inflammation.
- Corticosteroid Injections are injected directly into nodules to reduce inflammation.
- Oral Corticosteroids are ingested to reduce inflammation.
- Other Ointments with menthol or phenol cool and soothe itchy skin.
- Capsaicin Cream uses the heat in your body to block nerve messages.
- Oral Antihistamines are ingested antihistamines.
- SSRIs alter serotonin signals in the skin.
Habit reversal therapy is often needed, in addition to medications, to help patients reduce the amount of scratching, which can be very habit-forming. Other treatments can include cryotherapy, photochemotherapy, and immunosuppressants if the common treatments are not effective.
Even with a healthy amount of available treatment options, most people never have a complete resolution of the nodules; therefore, clinical studies to test new treatments are needed to find different and better ways to treat or even cure PN.
ActivMed Practices & Research, Inc. is currently seeking patients interested in helping to evaluate new options that may potentially help treat certain PN symptoms. Qualified candidates who participate will receive study-related care at no cost. Compensation is available for travel. If you or someone you know is suffering from the chronic itch and nodules associated with PN, this study may be a great opportunity. To learn more and to see how you or someone you love may qualify for a PN study, please click HERE.
References:
https://www.aocd.org/page/PrurigoNodularis
https://rarediseases.info.nih.gov/diseases/7480/prurigo-nodularis
Psoriasis is a disease that causes red, scaly patches to appear on the skin. It typically occurs on places like knees, scalp, and elbows, but can really show up anywhere. The uncomfortable rash can sometimes itch or burn. Psoriasis doesn’t stop at the skin. While the physical struggles associated with psoriasis can be considerable, the disease can also affect your mental and emotional health.
According to the National Psoriasis Foundation, people with psoriasis are more likely to suffer from depression. It’s even been said that depression is the number one comorbidity of psoriasis. Why is that? Some doctors believe that biological changes that cause psoriasis may play a part. The stigma associated with visible psoriasis can also make people depressed.
For most people with psoriasis, the red, scaly patches can be embarrassing. Many people will opt to wear long sleeves to conceal their psoriasis, and in the summer this is especially hard as heat and sweat can make psoriasis worse. While you may be anxious about showing too much skin, you don’t want to allow yourself to become overheated.
Many people with psoriasis will notice that their symptoms seem to improve during the summer months. While you may notice a reduction in your skin patches with added sunlight, remember to limit your sun exposure! Getting burnt could trigger a flare.
While psoriasis is one of the most common skin diseases, there is no cure. If you or someone you love is struggling to manage psoriasis symptoms, ActivMed is currently enrolling in studies for those seeking new treatment options. Qualified candidates who participate will receive study-related care at no cost and receive compensation for travel. To learn more and see how you or someone you love may qualify for a study at our Beverly location click HERE or at our Portsmouth site, click HERE.
Atopic dermatitis, also known as eczema, is a condition that causes skin to be red and itchy. The itching can be so uncomfortable it can get in the way of daily activities and cause problems when it comes to sleeping. It most commonly appears on the face, backs of the knees, insides of the elbows, hands and scalp.
The National Eczema Association estimates that over 31 million people in the U.S. have some form of eczema. Unfortunately, there are a lot of misconceptions surrounding this common skin condition. Here are just a few to help you understand eczema a little bit better.
- Eczema is contagious. This is a big one we hear all the time. You can’t ‘catch’ eczema from someone who has the disease and you can’t give it to someone by touching them if you have it.
- Eczema and acne are the same. This is false. The small bumps that eczema can cause are not acne.
- Eczema is caused by bad hygiene. The cause of the disease has nothing to do with personal hygiene. According to WebMD, doctors think eczema is caused by a combination of factors including combination of environmental, genetic and immune system factors.
- Eczema is caused by stress. While stress can trigger eczema and make it worse, stress does not cause eczema.
- Eczema can be cured. While there’s currently no cure for eczema, the condition can be better managed by knowing your personal triggers and making a treatment plan based upon that information.
Researchers at ActivMed are currently studying potential new eczema treatment options. If you or someone you love is struggling to manage eczema symptoms, you may be eligible to participate in a research study. Qualified participants are closely evaluated by board-certified dermatologists and other medical professionals, and may even gain access to new treatments before they are available to the general public. Compensation is also available for travel expenses. To learn more, click HERE.